La Trobe
42145_Vella,L_2016.pdf (264.55 kB)

Focus on extracellular vesicles: exosomes and their role in protein trafficking and biomarker potential in Alzheimer's and Parkinson's disease

Download (264.55 kB)
journal contribution
posted on 2023-01-10, 23:01 authored by LJ Vella, Andrew HillAndrew Hill, Lesley SimLesley Sim
Growing evidence indicates that small extracellular vesicles, called exosomes, are prominent mediators of neurodegenerative diseases such as prion, Alzheimer’s and Parkinson’s disease. Exosomes contain neurodegenerative disease associated proteins such as the prion protein, β-amyloid and α-synuclein. Only demonstrated so far in vivo with prion disease, exosomes are hypothesised to also facilitate the spread of β-amyloid and α-synuclein from their cells of origin to the extracellular environment. In the current review, we will discuss the role of exosomes in Alzheimer’s and Parkinson’s disease including their possible contribution to disease propagation and pathology and highlight their utility as a diagnostic in neurodegenerative disease.

Funding

Andrew F. Hill is supported by a National Health and Medical Research Council (NHMRC) Senior Research Fellowship.

History

Publication Date

2016-02-06

Journal

International Journal of Molecular Sciences

Volume

17

Issue

2

Article Number

173

Pagination

20p.

Publisher

MDPI

ISSN

1661-6596

Rights Statement

© 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).

Usage metrics

    Journal Articles

    Categories

    No categories selected

    Licence

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC