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Five-year changes in anterior segment parameters in an older population in urban southern China: the Liwan Eye Study

journal contribution
posted on 2021-01-18, 00:01 authored by Yu Jiang, Decai Wang, Wei Wang, Feng Chen, Lanhua Wang, Jane ScheetzJane Scheetz, Wenyong Huang, Shengsong Huang, Mingguang He
© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. Purpose To investigate the 5-year changes in static and dynamic anterior segment optical coherence tomography (AS-OCT) parameters and their predictors. Methods This was a prospective, population-based cohort study of people aged 50 years and older residing in the Liwan District, Guangzhou, China. Standardised AS-OCT scans were performed in November 2008 and November 2013 under dark and light conditions. Customised software was used to analyse horizontal AS-OCT images. Parameters in dark and measurements of light-to-dark changes were used for analyses. Results A total of 186 (71.8%) subjects underwent AS-OCT twice, 5 years apart and were included for analyses. The mean age in 2008 was 64.7±7.0 years, and 60.2% were women. The anterior chamber width (ACW) decreased from 11.74±0.44 mm in 2008 to 11.60±0.37 mm in 2013 (p=0.001). There was a trend towards a decrease in dynamic capacity (light-to-dark changes) in the anterior segment, with decreased iris thickness at 750 μm ( "IT750), "ACW, Δanterior chamber area (ACA) and Δpupil diameter at 5 years (all p<0.05). After adjusting for age and sex, the following baseline parameters were associated with a greater decrease rate in trabecular iris space area at 500 μm (TISA500) at 5 years: TISA500, IT750 and ACA in dark (p<0.001 for all). Conclusions Anterior chamber angle width decreased and the amount of light-to-dark changes declined during 5-year follow-up. Subjects with greater height, wider angle width and thicker iris at baseline have greater angle narrowing at follow-up.


This research was supported in part by the grant from the Fundamental Research Funds of the State Key of Ophthalmology, National Natural Science Foundation of China (81420108008 81570843H1204), Science and Technology Planning Project of Guangdong Province, China (2013B20400003). MH receives support from the University of Melbourne at Research Accelerator Program and the CERA Foundation. The Centre for Eye Research Australia receives Operational Infrastructure Support from the Victorian State Government. No additional external funding was received.


Publication Date



British Journal of Ophthalmology






6p. (p. 582-587)





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