La Trobe
EMT and Exos manuscript_revised_final_061016.docx (313.72 kB)

Extracellular vesicles: their role in cancer biology and epithelial-mesenchymal transition

Download (313.72 kB)
journal contribution
posted on 11.08.2021, 05:01 by Shashi Kumar Shashi Gopal Krishnan, David GreeningDavid Greening, Alin Rai, Maoshan Chen, Rong Xu, Adnan ShafiqAdnan Shafiq, Rommel A Mathias, HJ Zhu, Richard SimpsonRichard Simpson
Cell-cell communication is critical across an assortment of physiological and pathological processes. Extracellular vesicles (EVs) represent an integral facet of intercellular communication largely through the transfer of functional cargo such as proteins, messenger RNAs (mRNAs), microRNA (miRNAs), DNAs and lipids. EVs, especially exosomes and shed microvesicles, represent an important delivery medium in the tumour micro-environment through the reciprocal dissemination of signals between cancer and resident stromal cells to facilitate tumorigenesis and metastasis. An important step of the metastatic cascade is the reprogramming of cancer cells from an epithelial to mesenchymal phenotype (epithelial-mesenchymal transition, EMT), which is associated with increased aggressiveness, invasiveness and metastatic potential. There is now increasing evidence demonstrating that EVs released by cells undergoing EMT are reprogrammed (protein and RNA content) during this process. This review summarises current knowledge of EV-mediated functional transfer of proteins and RNA species (mRNA, miRNA, long non-coding RNA) between cells in cancer biology and the EMT process. An in-depth understanding of EVs associated with EMT, with emphasis on molecular composition (proteins and RNA species), will provide fundamental insights into cancer biology.

Funding

D.W.G. is supported by a LIMS Molecular Biology Stone Fellowship, La Trobe University Research Focus Area Leadership Grant and La Trobe University Start-up Fund. R.A.M. is supported by the National Health and Medical Research Council of Australia Early Career CJ Martin Fellowship APP1037043. S.K.G., A.R., M.C., R.X. and A.S. are supported by La Trobe University Postgraduate Scholarships.

History

Publication Date

01/01/2017

Journal

Biochemical Journal

Volume

474

Issue

1

Pagination

25p. (p. 21-45)

Publisher

Portland Press

ISSN

0264-6021

Rights Statement

The Author reserves all moral rights over the deposited text and must be credited if any re-use occurs. Documents deposited in OPAL are the Open Access versions of outputs published elsewhere. Changes resulting from the publishing process may therefore not be reflected in this document. The final published version may be obtained via the publisher’s DOI. Please note that additional copyright and access restrictions may apply to the published version.