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Exploring a potential Achilles heel of Mycobacterium tuberculosis: defining the ClpC1 interactome

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journal contribution
posted on 23.03.2021, 04:51 by David DouganDavid Dougan, Regina Alver, Kuersad Turgay
Protein degradation plays a vital role in the correct maintenance of a cell, not only under normal physiological conditions but also in response to stress. In the human pathogen Mtb, this crucial cellular task is performed by several ATPase associated with diverse cellular activities proteases including ClpC1P. Ziemski et al. performed a bacterial adenylate cyclase two-hybrid screen to identify ClpC1 substrates and showed the Type II TA systems represent a major group of ClpC1-interacting proteins. Comment on: https://doi.org/10.1111/febs.15335.

Funding

The work in the Lab of KT is supported by the Max Planck Society and the Deutsche Forschungsgemeinschaft.

History

Publication Date

01/01/2021

Journal

The FEBS Journal

Volume

288

Issue

1

Pagination

4p. (p. 95-98)

Publisher

Wiley

ISSN

1742-464X

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