La Trobe
Exosomes and their roles in immune regulation and cancer.pdf (312.05 kB)

Exosomes and their roles in immune regulation and cancer

Download (312.05 kB)
journal contribution
posted on 12.08.2021, 06:32 by David GreeningDavid Greening, SK Gopal, Rong Xu, Richard SimpsonRichard Simpson, Weisan ChenWeisan Chen
Exosomes, a subset of extracellular vesicles (EVs), function as a mode of intercellular communication and molecular transfer. Exosomes facilitate the direct extracellular transfer of proteins, lipids, and miRNA/mRNA/DNAs between cells in vitro and in vivo. The immunological activities of exosomes affect immunoregulation mechanisms including modulating antigen presentation, immune activation, immune suppression, immune surveillance, and intercellular communication. Besides immune cells, cancer cells secrete immunologically active exosomes that influence both physiological and pathological processes. The observation that exosomes isolated from immune cells such as dendritic cells (DCs) modulate the immune response has enforced the way these membranous vesicles are being considered as potential immunotherapeutic reagents. Indeed, tumour- and immune cell-derived exosomes have been shown to carry tumour antigens and promote immunity, leading to eradication of established tumours by CD8+ T cells and CD4+ T cells, as well as directly suppressing tumour growth and resistance to malignant tumour development. Further understanding of these areas of exosome biology, and especially of molecular mechanisms involved in immune cell targeting, interaction and manipulation, is likely to provide significant insights into immunorecognition and therapeutic intervention. Here, we review the emerging roles of exosomes in immune regulation and the therapeutic potential in cancer.

Funding

The authors are supported, in part, by the NHMRC program grant 567122 (W.C.), NHMRC program grant 487922 (RJ.S.), and NHMRC project grant 1057741 (RJ.S.). S.K.G. and R.X are supported by La Trobe University Postgraduate Scholarships.

History

Publication Date

01/01/2015

Journal

Seminars in Cell and Developmental Biology

Volume

40

Pagination

10p. (p. 72-81)

Publisher

Elsevier

ISSN

1084-9521

Rights Statement

The Author reserves all moral rights over the deposited text and must be credited if any re-use occurs. Documents deposited in OPAL are the Open Access versions of outputs published elsewhere. Changes resulting from the publishing process may therefore not be reflected in this document. The final published version may be obtained via the publisher’s DOI. Please note that additional copyright and access restrictions may apply to the published version.