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Estrogen receptor alpha deficiency in cardiomyocytes reprograms the heart-derived extracellular vesicle proteome and induces obesity in female mice

journal contribution
posted on 2024-05-15, 03:11 authored by Yow Keat ThamYow Keat Tham, Bianca C Bernardo, Bethany ClaridgeBethany Claridge, Gunes S Yildiz, Liesel Min-Linn Woon, Simon Bond, Haoyun Fang, Jenny YY Ooi, Aya Matsumoto, Jieting Luo, Celeste MK Tai, Claudia A Harmawan, Helen Kiriazis, Daniel G Donner, Natalie A Mellett, E Dale Abel, Sohaib A Khan, David P De Souza, Sheik Nadeem Elahee Doomun, Kevin Liu, Ruidong XiangRuidong Xiang, Manika Singh, Michael Inouye, Peter MeiklePeter Meikle, Kate L Weeks, Brian DrewBrian Drew, David GreeningDavid Greening, Julie McMullenJulie McMullen

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Funding

This work was supported by the National Heart Foundation of Australia (Grant-In-Aid: ID G 08M 3760 and G 11M 6111 to J.R.M.; Vanguard 105072 to D.G.), National Health and Medical Research Council (NHMRC) project grant (1139489 and 1057741 to D.G.), Future Fund (MRF1201805 to D.G.), Pankind (to D.G.) and the Victorian Government’s Operational Infrastructure Support Program. J.R.M. was supported by a NHMRC Senior Research Fellowship (grant no. 1078985) and is supported by a Baker Fellowship. B.C.B. is supported by an Alice Baker and Eleanor Shaw Fellowship (The Baker Foundation, Australia). K.L.W. is supported by a National Heart Foundation Future Leader Fellowship (award ID 102539). B.C. and H.F. are supported by an Australian Government Training Program (RTP) scholarship and Baker Institute Bright Sparks Scholarship Top Up. E.D.A. is supported by the American Heart Association (20SFRN35120123). The metabolomics component of this project used NCRIS-enabled Metabolomics Australia infrastructure at the University of Melbourne and was funded through BioPlatforms Australia.

History

Publication Date

2023-03-01

Journal

Nature Cardiovascular Research

Volume

2

Pagination

22p. (p. 268-289)

Publisher

Springer Nature

ISSN

2731-0590

Rights Statement

© The Author(s), under exclusive licence to Springer Nature Limited 2023

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