Enteric pathogen infection and consequences for child growth in young Aboriginal Australian children: a cross-sectional study
journal contributionposted on 21.07.2021, 06:41 by S Hanieh, S Mahanty, G Gurruwiwi, T Kearns, R Dhurrkay, V Gondarra, Jennifer ShieldJennifer Shield, N Ryan, F Azzato, SA Ballard, N Orlando, S Nicholson, K Gibney, J Brimblecombe, W Page, LC Harrison, BA Biggs, Y Dhamarandji, D Djilimara, E Bungawara, L Dhamarandji, J Djiliri, J Gatti, J Kraayenhof, N Goveas
Background: To determine the prevalence of enteric infections in Aboriginal children aged 0–2 years using conventional and molecular diagnostic techniques and to explore associations between the presence of pathogens and child growth. Methods: Cross-sectional analysis of Aboriginal children (n = 62) residing in a remote community in Northern Australia, conducted from July 24th - October 30th 2017. Stool samples were analysed for organisms by microscopy (directly in the field and following fixation and storage in sodium-acetate formalin), and by qualitative PCR for viruses, bacteria and parasites and serology for Strongyloides-specific IgG. Child growth (height and weight) was measured and z scores calculated according to WHO growth standards. Results: Nearly 60% of children had evidence for at least one enteric pathogen in their stool (37/62). The highest burden of infection was with adenovirus/sapovirus (22.9%), followed by astrovirus (9.8%) and Cryptosporidium hominis/parvum (8.2%). Non-pathogenic organisms were detected in 22.5% of children. Ten percent of children had diarrhea at the time of stool collection. Infection with two or more pathogens was negatively associated with height for age z scores (− 1.34, 95% CI − 2.61 to − 0.07), as was carriage of the non-pathogen Blastocystis hominis (− 2.05, 95% CI - 3.55 to − 0.54). Conclusions: Infants and toddlers living in this remote Northern Australian Aboriginal community had a high burden of enteric pathogens and non-pathogens. The association between carriage of pathogens/non-pathogens with impaired child growth in the critical first 1000 days of life has implications for healthy child growth and development and warrants further investigation. These findings have relevance for many other First Nations Communities that face many of the same challenges with regard to poverty, infections, and malnutrition.
This work was supported through a grant from the Hallmark Indigenous Research Initiative at the University of Melbourne. The funder had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript.
JournalBMC Infectious Diseases
Article Number9 (2021)
Rights StatementThe Author reserves all moral rights over the deposited text and must be credited if any re-use occurs. Documents deposited in OPAL are the Open Access versions of outputs published elsewhere. Changes resulting from the publishing process may therefore not be reflected in this document. The final published version may be obtained via the publisher’s DOI. Please note that additional copyright and access restrictions may apply to the published version.
Infectious DiseasesEnteric infectionChild growthAboriginalHeight for age z scoresChild Health and Nutrition Study teamCryptosporidiumAdenoviruses, HumanSapovirusAdenovirus Infections, HumanAstroviridae InfectionsCaliciviridae InfectionsCryptosporidiosisGastroenteritisDiarrheaCross-Sectional StudiesPolymerase Chain ReactionChild, PreschoolInfantInfant, NewbornOceanic Ancestry GroupMamastrovirus