La Trobe
Emerging roles of exosomes during epithelial-mesenchymal transition and cancer progression.pdf (558.72 kB)

Emerging roles of exosomes during epithelial-mesenchymal transition and cancer progression

Download (558.72 kB)
journal contribution
posted on 12.08.2021, 06:32 by David GreeningDavid Greening, SK Gopal, RA Mathias, L Liu, J Sheng, H-J Zhu, Richard SimpsonRichard Simpson
Epithelial-mesenchymal transition (EMT) is a highly conserved process defined by the loss of epithelial characteristics, and acquisition of the mesenchymal phenotype. In addition to its central role in development, EMT has been implicated as a cellular process during tumourigenesis which facilitates tumour cell invasion and metastasis. The EMT process has been largely defined by signal transduction networks and transcriptional factors that activate mesenchymal-associated gene expression. Knowledge of secretome components that influence EMT including secreted proteins/peptides and membrane-derived extracellular vesicles (EVs) (i.e., exosomes) has emerged. Here we review EV cargo associated with inducing the hallmarks of EMT and cancer progression, modulators of cell transformation, invasion/migration, angiogenesis, and components involved in establishing the metastatic niche.

Funding

The authors are supported, in part, by the National Health and Medical Research Council of Australia Programme grant 487922 (RJ.S.), project grant 1057741 (RJ.S), project 628727 (HJ.Z), Melbourne Research Grant Support Scheme (Melbourne University, HJ.Z) and Early Career CJ Martin Fellowship APP1037043 (R.A.M.). S.K.G. is supported by a La Trobe University Postgraduate Scholarship. L.L and J.S are receipts of Melbourne International Research Scholarship (Melbourne University).

History

Publication Date

01/01/2015

Journal

Seminars in Cell and Developmental Biology

Volume

40

Pagination

12p. (p. 60-71)

Publisher

Elsevier

ISSN

1084-9521

Rights Statement

The Author reserves all moral rights over the deposited text and must be credited if any re-use occurs. Documents deposited in OPAL are the Open Access versions of outputs published elsewhere. Changes resulting from the publishing process may therefore not be reflected in this document. The final published version may be obtained via the publisher’s DOI. Please note that additional copyright and access restrictions may apply to the published version.