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Elucidating the role of extracellular vesicles in pancreatic cancer

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journal contribution
posted on 10.12.2021, 01:38 by Akbar Lulu MarzanAkbar Lulu Marzan, Sarah StewartSarah Stewart
Pancreatic cancer is one of the deadliest cancers worldwide, with a 5‐year survival rate of less than 10%. This dismal survival rate can be attributed to several factors including insufficient diagnostics, rapid metastasis and chemoresistance. To identify new treatment options for improved patient outcomes, it is crucial to investigate the underlying mechanisms that contribute to pancreatic cancer progression. Accumulating evidence suggests that extracellular vesicles, including exosomes and microvesicles, are critical players in pancreatic cancer progression and chemoresistance. In addition, extracellular vesicles also have the potential to serve as promising biomarkers, therapeutic targets and drug delivery tools for the treatment of pancreatic cancer. In this review, we aim to summarise the current knowledge on the role of extracellular vesicles in pancreatic cancer progression, metastasis, immunity, metabolic dysfunction and chemoresistance, and discuss their potential roles as biomarkers for early diagnosis and drug delivery vehicles for treatment of pancreatic cancer.

History

Publication Date

12/11/2021

Journal

Cancers

Volume

13

Issue

22

Article Number

5669

Pagination

17p.

Publisher

MDPI

ISSN

2072-6694

Rights Statement

© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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