2019 - WHJ - Hussein_et_al-Does Vitamin D3 Supplementation Affect the Outcome in Patients with Acute ST elevation MI.pdf (443.35 kB)Download file
Does Vitamin D3 Supplementation Affect the Outcome of Patients with Acute ST Segment Elevation Myocardial Infarction?
journal contributionposted on 2022-01-16, 23:01 authored by Mohammad Al Hussein, Najah Hadi, Rabab Salman, Anwar AlZurfi, Hameed Shaalan, Hayder Al-AubaidyHayder Al-Aubaidy
Background: Acute Myocardial Infarction (AMI) is one of the major causes of mortality and morbidity. Vitamin D deficiency plays an important role in pathophysiology of CAD, including atherosclerosis and endothelial dysfunction. Objectives: This study aims to highlight the short-term effects of vitamin D3 supplementation on inflammation levels in hospitalized patients with acute ST-segment elevation myocardial infarction (STEMI). Study group: Forty-four patients with clinical diagnosis of STEMI were included in this study. Methods: Participants were randomized into two groups: Group I (intervention Group) received the standard treatment for AMI plus vitamin D3 5000 IU/day for 5 days. Group II (Control Group) received the standard treatment with no vitamin D3 supplementation. After taking history, performing clinical examination and electrocardiography, venous blood samples were taken at two intervals: Time zero (during hospital admission), and after 5 days follow-up for the measurement of 25-hydroxy vitamin D and selected inflammatory markers (troponin I, high sensitivity Creactive protein, Interleukin-6) and WBC counts. Results: There was a significant increase in the level of 25- hydroxy vitamin D in the Intervention Group (30.1 ± 13.2 ng/ml) after 5 days of its supplementation, as compared to the baseline (24.2 ± 13.3 ng/ml), P<0.001. However, this was not associated with a significant reduction in the degree of inflammation, except for the levels of interleukin-6 (baseline level was 27.45 ± 9.85 pg/ml, and post-treatment level was 21.52 ± 8.49 pg/ml, P<0.001. Such differences were not found in the Control Group. Conclusion: Vitamin D3 supplementation had no significant effects on the outcomes of the acute inflammatory response in patients with acute STEMI, in spite of the significant inverse correlation between baseline vitamin D levels and interlukin-6 levels among all participants of this study.