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Dictyostelium discoideum: A Model System for Neurological Disorders

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journal contribution
posted on 19.09.2022, 06:49 authored by Claire StoreyClaire Storey, RSB Williams, Paul FisherPaul Fisher, Sarah AnnesleySarah Annesley
Background: The incidence of neurological disorders is increasing due to population growth and extended life expectancy. Despite advances in the understanding of these disorders, curative strategies for treatment have not yet eventuated. In part, this is due to the complexities of the disorders and a lack of identification of their specific underlying pathologies. Dictyostelium dis-coideum has provided a useful, simple model to aid in unraveling the complex pathological characteristics of neurological disorders including Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, neuronal ceroid lipofuscinoses and lissencephaly. In addition, D. discoideum has proven to be an innovative model for pharmaceutical research in the neurological field. Scope of review: This review describes the contributions of D. discoideum in the field of neurological research. The contin-ued exploration of proteins implicated in neurological disorders in D. discoideum may elucidate their pathological roles and fast-track curative therapeutics.

History

Publication Date

28/01/2022

Journal

Cells

Volume

11

Issue

3

Article Number

463

Pagination

31p.

Publisher

MDPI

ISSN

2073-4409

Rights Statement

© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).