sorry, we can't preview this file
...but you can still download 1153427_Jee,A_2021.pdf
1153427_Jee,A_2021.pdf (3.55 MB)
Diagnosis and management of connective tissue disease-associated interstitial lung disease in Australia and New Zealand: A position statement from the Thoracic Society of Australia and New Zealand
journal contribution
posted on 2021-01-21, 04:51 authored by AS Jee, R Sheehy, P Hopkins, TJ Corte, C Grainge, LK Troy, K Symons, LM Spencer, PN Reynolds, S Chapman, S de Boer, T Reddy, Anne HollandAnne Holland, DC Chambers, IN Glaspole, HE Jo, JF Bleasel, JP Wrobel, L Dowman, MJS Parker, ML Wilsher, NSL Goh, Y Moodley, GJ Keir© 2020 The Authors. Respirology published by John Wiley & Sons Australia, Ltd on behalf of Asian Pacific Society of Respirology. Pulmonary complications in CTD are common and can involve the interstitium, airways, pleura and pulmonary vasculature. ILD can occur in all CTD (CTD-ILD), and may vary from limited, non-progressive lung involvement, to fulminant, life-threatening disease. Given the potential for major adverse outcomes in CTD-ILD, accurate diagnosis, assessment and careful consideration of therapeutic intervention are a priority. Limited data are available to guide management decisions in CTD-ILD. Autoimmune-mediated pulmonary inflammation is considered a key pathobiological pathway in these disorders, and immunosuppressive therapy is generally regarded the cornerstone of treatment for severe and/or progressive CTD-ILD. However, the natural history of CTD-ILD in individual patients can be difficult to predict, and deciding who to treat, when and with what agent can be challenging. Establishing realistic therapeutic goals from both the patient and clinician perspective requires considerable expertise. The document aims to provide a framework for clinicians to aid in the assessment and management of ILD in the major CTD. A suggested approach to diagnosis and monitoring of CTD-ILD and, where available, evidence-based, disease-specific approaches to treatment have been provided.
Funding
This work was supported by the NHMRC Centre of Research Excellence in Pulmonary Fibrosis, Australia, which is funded by the NHMRC and supported by Foundation partner Boehringer Ingelheim and Program Partners Roche and Galapagos.
History
Publication Date
2021-01-01Journal
RespirologyVolume
26Issue
1Pagination
29p. (p. 23-51)Publisher
WileyISSN
1323-7799Rights Statement
The Author reserves all moral rights over the deposited text and must be credited if any re-use occurs. Documents deposited in OPAL are the Open Access versions of outputs published elsewhere. Changes resulting from the publishing process may therefore not be reflected in this document. The final published version may be obtained via the publisher’s DOI. Please note that additional copyright and access restrictions may apply to the published version.Publisher DOI
Usage metrics
Categories
Keywords
Science & TechnologyLife Sciences & BiomedicineRespiratory Systemclinical diagnosis and managementcollagen vascular diseaseconnective tissue diseaseinterstitial lung diseaseIDIOPATHIC PULMONARY-FIBROSISSTEM-CELL TRANSPLANTATIONCLINICALLY AMYOPATHIC DERMATOMYOSITISINTRAVENOUS PULSE CYCLOPHOSPHAMIDEPNEUMOCYSTIS-JIROVECII PNEUMONIAANCA-ASSOCIATED VASCULITISPLACEBO-CONTROLLED TRIALQUALITY-OF-LIFERHEUMATOID-ARTHRITISSYSTEMIC-SCLEROSIS