Maintaining high-affinity antibodies after vaccination may be important for long-lasting immunity to malaria, but data on induction and kinetics of affinity is lacking. In a phase 1 malaria vaccine trial, antibody affinity increased following a second vaccination but declined substantially over 12 months, suggesting poor maintenance of high-affinity antibodies.
Funding
This work was supported by the National Health and Medical Research Council, Australia (grant numbers 1173046 and 1092789 to J. B.); and Avtal om Lakarutbildning och Forskning (Region Skane/Lund University to K. P.). Funding to pay the open access publication charges for this article was provided by Burnet Institute.
Publication Date
2024-09-15Journal
Journal of Infectious DiseasesVolume
230Issue
3Pagination
5p. (p. e753-e757)Publisher
Oxford University PressISSN
0022-1899Rights Statement
© The Author(s) 2024. Published by Oxford University Press on behalf of Infectious Diseases Society of America.
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