La Trobe

Declining Antibody Affinity Over Time After Human Vaccination With a Plasmodium falciparum Merozoite Vaccine Candidate

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posted on 2024-10-08, 03:16 authored by Kristina EM Persson, Jessica L Horton, Liriye Kurtovic, James S McCarthy, Robin AndersRobin Anders, James G Beeson
Maintaining high-affinity antibodies after vaccination may be important for long-lasting immunity to malaria, but data on induction and kinetics of affinity is lacking. In a phase 1 malaria vaccine trial, antibody affinity increased following a second vaccination but declined substantially over 12 months, suggesting poor maintenance of high-affinity antibodies.

Funding

This work was supported by the National Health and Medical Research Council, Australia (grant numbers 1173046 and 1092789 to J. B.); and Avtal om Lakarutbildning och Forskning (Region Skane/Lund University to K. P.). Funding to pay the open access publication charges for this article was provided by Burnet Institute.

History

Publication Date

2024-09-15

Journal

Journal of Infectious Diseases

Volume

230

Issue

3

Pagination

5p. (p. e753-e757)

Publisher

Oxford University Press

ISSN

0022-1899

Rights Statement

© The Author(s) 2024. Published by Oxford University Press on behalf of Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.

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