La Trobe
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Convergent evolution of defensin sequence, structure and function

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journal contribution
posted on 05.01.2021, 22:30 by Thomas Shafee, Fung Lay, Thanh Phan, Marilyn Anderson, Mark Hulett
© 2016, Springer International Publishing. Defensins are a well-characterised group of small, disulphide-rich, cationic peptides that are produced by essentially all eukaryotes and are highly diverse in their sequences and structures. Most display broad range antimicrobial activity at low micromolar concentrations, whereas others have other diverse roles, including cell signalling (e.g. immune cell recruitment, self/non-self-recognition), ion channel perturbation, toxic functions, and enzyme inhibition. The defensins consist of two superfamilies, each derived from an independent evolutionary origin, which have subsequently undergone extensive divergent evolution in their sequence, structure and function. Referred to as the cis- and trans-defensin superfamilies, they are classified based on their secondary structure orientation, cysteine motifs and disulphide bond connectivities, tertiary structure similarities and precursor gene sequence. The utility of displaying loops on a stable, compact, disulphide-rich core has been exploited by evolution on multiple occasions. The defensin superfamilies represent a case where the ensuing convergent evolution of sequence, structure and function has been particularly extreme. Here, we discuss the extent, causes and significance of these convergent features, drawing examples from across the eukaryotes.

Funding

The authors would like to thank the financial support of the Australian Research council (Grant DP150104386), Hexima Ltd, and La Trobe University.

Australian Research Council | DP150104386

Hexima Ltd

La Trobe University

History

Publication Date

01/02/2017

Journal

Cellular and Molecular Life Sciences

Volume

74

Issue

4

Pagination

20p. (p. 663-682)

Publisher

Springer

ISSN

1420-682X

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