journal contribution
posted on 2024-05-30, 04:39 authored by Michiel MA van Buuren, Noortje S Riedstra, Myrthe A van den Berg, Fleur DEM Boel, Harbeer Ahedi, Vahid Arbabi, Nigel K Arden, Sita MA Bierma-Zeinstra, Cindy G Boer, Flavia Cicuttini, Timothy F Cootes, Kay CrossleyKay Crossley, David Felson, Willem Paul Gielis, Joshua HeereyJoshua Heerey, Graeme Jones, Stefan Kluzek, Nancy E Lane, Claudia Lindner, John A Lynch, J Van Meurs, Andrea MoslerAndrea Mosler, Amanda E Nelson, M Nevitt, Edwin Oei, Jos Runhaar, Jinchi Tang, Harrie Weinans, Rintje Agricola ABSTRACT: Purpose: Hip osteoarthritis (OA) is a major cause of pain and disability worldwide. Lack of effective therapies may reflect poor knowledge on its aetiology and risk factors, and result in the management of end-stage hip OA with costly joint replacement. The Worldwide Collaboration on OsteoArthritis prediCtion for the Hip (World COACH) consortium was established to pool and harmonise individual participant data from prospective cohort studies. The consortium aims to better understand determinants and risk factors for the development and progression of hip OA, to optimise and automate methods for (imaging) analysis, and to develop a personalised prediction model for hip OA. Participants: World COACH aimed to include participants of prospective cohort studies with ≥200 participants, that have hip imaging data available from at least 2 time points at least 4 years apart. All individual participant data, including clinical data, imaging (data), biochemical markers, questionnaires and genetic data, were collected and pooled into a single, individual-level database. Findings to date: World COACH currently consists of 9 cohorts, with 38 021 participants aged 18–80 years at baseline. Overall, 71% of the participants were women and mean baseline age was 65.3±8.6 years. Over 34 000 participants had baseline pelvic radiographs available, and over 22 000 had an additional pelvic radiograph after 8–12 years of follow-up. Even longer radiographic follow-up (15–25 years) is available for over 6000 of these participants. Future plans: The World COACH consortium offers unique opportunities for studies on the relationship between determinants/risk factors and the development or progression of hip OA, by using harmonised data on clinical findings
Funding
The World COACH consortium itself has been funded through research grants by the Dutch Arthritis Society (grant no. 18-2-203 and 21-1-205), the Dutch Research Council (NWO Veni grant scheme no. 09150161910071), and Erasmus MC, University Medical Center Rotterdam (Erasmus MC Fellowship). MvB is funded by the Dutch Arthritis Society (research grants 18-2-203 and 21-1-205) and by an Erasmus MC Fellowship grant. NR, MvdB and FB are funded by the Dutch Arthritis Society (research grant 21-1-205). NA is funded by the Versus Arthritis Centre for Sport, Exercise & Osteoarthritis Research. SBZ is funded through independent research grants by the European Research Council (ERC), the Dutch Arthritis Society, and The Netherlands Organisation for Health Research and Development (ZonMw). CB and JvM are funded by the Dutch Arthritis Society (LLP-34). TC is funded by research grants from the Engineering and Physical Sciences Research Council (EPSRC) UK, the Medical Research Council (MRC) UK, and the Wellcome Trust. KC and JH are funded by the National Health and Medical Research Council (NHMRC) Australia (GNT GNT1088683), AM is funded by an NHMRC Australia Early Career Fellowship (GNT1156674). DF is funded by a research grant from the National Institutes of Health (NIH) (AR072571). CL is funded by a research grant from the MRC UK (MR/S00405X/1) as well as a Sir Henry Dale Fellowship jointly funded by the Wellcome Trust and the Royal Society (223267/Z/21/Z). This research was funded in whole, or in part, by the Wellcome Trust (Grant number 223267/Z/21/Z). AN is funded by the Centers for Disease Control and Prevention (CDC) (U01DP006266 and U01DP003206; Association of Schools of Public Health/CDC S043, S1734, S3486), and the NIH and National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) (P60AR30701, P60AR049465, P60AR064166 and P30AR072580). MN is funded by research grants from the NIH. JT is funded by the China Scholarship Council (CSC). HW is funded by resear
History
Publication Date
2024-04-18Journal
BMJ OpenVolume
14Issue
4Article Number
e077907Pagination
13p.Publisher
BMJ Publishing GroupISSN
2044-6055Rights Statement
© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY. Published by BMJ.
