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Cathepsin F of Teladorsagia circumcincta is a recently evolved cysteine protease
journal contributionposted on 2020-11-13, 00:30 authored by Sarah SloanSarah Sloan, Caitlin Jenvey, Callum CairnsCallum Cairns, Michael StearMichael Stear
© The Author(s) 2020. Parasitic cysteine proteases are involved in parasite stage transition, invasion of host tissues, nutrient uptake, and immune evasion. The cysteine protease cathepsin F is the most abundant protein produced by fourth-stage larvae (L4) of the nematode Teladorsagia circumcincta, while its transcript is only detectable in L4 and adults. T. circumcincta cathepsin F is a recently evolved cysteine protease that does not fall clearly into either of the cathepsin L or F subfamilies. This protein exhibits characteristics of both cathepsins F and L, and its phylogenetic relationship to its closest homologs is distant, including proteins of closely related nematodes of the same subfamily.
The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This research was funded by a grant from La Trobe University.
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Science & TechnologyLife Sciences & BiomedicineEvolutionary BiologyMathematical & Computational BiologyCysteine proteasecathepsinTeladorsagia circumcinctabioinformaticshomology modelinggastrointestinal nematodeOSTERTAGIA-CIRCUMCINCTAFASCIOLA-HEPATICASHEEPSTRONGYLIDANEMATODESRESISTANCEIMMUNITYSITESPREDICTIONEVOLUTIONBioinformatics