File(s) stored somewhere else
Please note: Linked content is NOT stored on La Trobe and we can't guarantee its availability, quality, security or accept any liability.
Cathepsin F of Teladorsagia circumcincta is a recently evolved cysteine protease
journal contributionposted on 13.11.2020, 00:30 authored by Sarah SloanSarah Sloan, Caitlin Jenvey, Callum CairnsCallum Cairns, Michael StearMichael Stear
© The Author(s) 2020. Parasitic cysteine proteases are involved in parasite stage transition, invasion of host tissues, nutrient uptake, and immune evasion. The cysteine protease cathepsin F is the most abundant protein produced by fourth-stage larvae (L4) of the nematode Teladorsagia circumcincta, while its transcript is only detectable in L4 and adults. T. circumcincta cathepsin F is a recently evolved cysteine protease that does not fall clearly into either of the cathepsin L or F subfamilies. This protein exhibits characteristics of both cathepsins F and L, and its phylogenetic relationship to its closest homologs is distant, including proteins of closely related nematodes of the same subfamily.
The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This research was funded by a grant from La Trobe University.
Rights StatementThe Author reserves all moral rights over the deposited text and must be credited if any re-use occurs. Documents deposited in OPAL are the Open Access versions of outputs published elsewhere. Changes resulting from the publishing process may therefore not be reflected in this document. The final published version may be obtained via the publisher’s DOI. Please note that additional copyright and access restrictions may apply to the published version.
Science & TechnologyLife Sciences & BiomedicineEvolutionary BiologyMathematical & Computational BiologyCysteine proteasecathepsinTeladorsagia circumcinctabioinformaticshomology modelinggastrointestinal nematodeOSTERTAGIA-CIRCUMCINCTAFASCIOLA-HEPATICASHEEPSTRONGYLIDANEMATODESRESISTANCEIMMUNITYSITESPREDICTIONEVOLUTIONBioinformatics