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CT Attenuation correction and its impact on image quality of myocardial perfusion imaging in coronary artery disease: A systematic review

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posted on 2022-03-25, 05:47 authored by Claire Farrell, JA Pinson, Amy DennettAmy Dennett
Myocardial perfusion imaging is a non-invasive procedure that plays an integral role in the diagnosis and management of coronary artery disease. With the routine use of computerised tomography attenuation correction (CTAC) in myocardial perfusion imaging still under debate, the aim of this review was to determine the impact of CTAC on image quality in myocardial perfusion imaging. Medline, Embase and CINAHL were searched from the earliest available time until August 2019. Methodological quality was assessed using the Quality Assessment of Diagnostic Accuracy Studies version 2. Details pertaining to image quality and diagnostic accuracy were analysed, and results summarised descriptively. Three studies with ‘unclear’ risk of bias and low applicability concerns (1002 participants) from a yield of 2725 articles were identified. Two studies demonstrated an increase in image quality, and one study found no difference in image quality when using CTAC compared to no attenuation correction. Benefits of CTAC for improving image quality remain unclear. Given the potential exposure risk with the addition of CTAC, patient and clinician factors should inform decision making for use of CTAC in myocardial perfusion imaging for coronary artery disease.


Publication Date



Asia Oceania Journal of Nuclear Medicine and Biology






8p. (p. 31-38)


Mashhad University of Medical Sciences in collaboration with AOFNMB (Asia Oceania Federation of Nuclear Medicine & Biology)



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©2021 [Mashhad University of Medical Sciences]. All rights reserved. This is an Open Access journal distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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