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Bioinformatic analysis of eosinophil activity and its implications for model and target species
journal contributionposted on 14.01.2021, 22:38 by Caitlin Jenvey, Dalal Sader H Alenizi, Fazel Almasi, Callum Cairns, A Holmes, Sarah Sloan, Michael Stear
Copyright © The Author(s), 2019. Published by Cambridge University Press. Eosinophils are important immune cells that have been implicated in resistance to gastrointestinal nematode (GIN) infections in both naturally and experimentally infected sheep. Proteins of particular importance appear to be IgA-Fc alpha receptor (FcαRI), C-C chemokine receptor type 3 (CCR3), proteoglycan 3 (PRG3, major basic protein 2) and EPX (eosinophil peroxidase). We used known human nucleotide sequences to search the ruminant genomes, followed by translation to protein and sequence alignments to visualize differences between sequences and species. Where a sequence was retrieved for cow, but not for sheep and goat, this was used additionally as a reference sequence. In this review, we show that eosinophil function varies among host species. Consequently, investigations into the mechanisms of ruminant immune responses to GIN should be conducted using the natural host. Specifically, we address differences in protein sequence and structure for eosinophil proteins.
Pagination8p. (p. 393-400)
PublisherCambridge University Press
Rights StatementThe Author reserves all moral rights over the deposited text and must be credited if any re-use occurs. Documents deposited in OPAL are the Open Access versions of outputs published elsewhere. Changes resulting from the publishing process may therefore not be reflected in this document. The final published version may be obtained via the publisher’s DOI. Please note that additional copyright and access restrictions may apply to the published version.
Science & TechnologyLife Sciences & BiomedicineParasitologyBioinformaticsCCR3eosinophilsEPXFc alpha RIgastrointestinal nematodesPRG3ruminantsMAJOR BASIC-PROTEINGASTROINTESTINAL NEMATODE INFECTIONHAEMONCHUS-CONTORTUS LARVAEEOTAXIN RECEPTOR CCR3TELADORSAGIA-CIRCUMCINCTAMOLECULAR-CLONINGTRICHOSTRONGYLUS-COLUBRIFORMISPROTECTIVE IMMUNITYHELMINTH INFECTIONIGA PRODUCTIONFcαRIAnimalsCattleCattle DiseasesComputational BiologyEosinophilsGastrointestinal DiseasesGoat DiseasesGoatsHumansNematode InfectionsSheepSheep DiseasesSheep, DomesticMycology & Parasitology