File(s) stored somewhere else
Please note: Linked content is NOT stored on La Trobe and we can't guarantee its availability, quality, security or accept any liability.
Bioinformatic analysis of eosinophil activity and its implications for model and target species
journal contribution
posted on 2021-01-14, 22:38 authored by Caitlin Jenvey, Dalal Sader H AleniziDalal Sader H Alenizi, Fazel AlmasiFazel Almasi, Callum CairnsCallum Cairns, A Holmes, Sarah SloanSarah Sloan, Michael StearMichael StearCopyright © The Author(s), 2019. Published by Cambridge University Press. Eosinophils are important immune cells that have been implicated in resistance to gastrointestinal nematode (GIN) infections in both naturally and experimentally infected sheep. Proteins of particular importance appear to be IgA-Fc alpha receptor (FcαRI), C-C chemokine receptor type 3 (CCR3), proteoglycan 3 (PRG3, major basic protein 2) and EPX (eosinophil peroxidase). We used known human nucleotide sequences to search the ruminant genomes, followed by translation to protein and sequence alignments to visualize differences between sequences and species. Where a sequence was retrieved for cow, but not for sheep and goat, this was used additionally as a reference sequence. In this review, we show that eosinophil function varies among host species. Consequently, investigations into the mechanisms of ruminant immune responses to GIN should be conducted using the natural host. Specifically, we address differences in protein sequence and structure for eosinophil proteins.
History
Publication Date
2020-04-01Journal
ParasitologyVolume
147Issue
4Pagination
8p. (p. 393-400)Publisher
Cambridge University PressISSN
0031-1820Rights Statement
The Author reserves all moral rights over the deposited text and must be credited if any re-use occurs. Documents deposited in OPAL are the Open Access versions of outputs published elsewhere. Changes resulting from the publishing process may therefore not be reflected in this document. The final published version may be obtained via the publisher’s DOI. Please note that additional copyright and access restrictions may apply to the published version.Publisher DOI
Usage metrics
Categories
No categories selectedKeywords
Science & TechnologyLife Sciences & BiomedicineParasitologyBioinformaticsCCR3eosinophilsEPXFc alpha RIgastrointestinal nematodesPRG3ruminantsMAJOR BASIC-PROTEINGASTROINTESTINAL NEMATODE INFECTIONHAEMONCHUS-CONTORTUS LARVAEEOTAXIN RECEPTOR CCR3TELADORSAGIA-CIRCUMCINCTAMOLECULAR-CLONINGTRICHOSTRONGYLUS-COLUBRIFORMISPROTECTIVE IMMUNITYHELMINTH INFECTIONIGA PRODUCTIONFcαRIAnimalsCattleCattle DiseasesComputational BiologyEosinophilsGastrointestinal DiseasesGoat DiseasesGoatsHumansNematode InfectionsSheepSheep DiseasesSheep, DomesticMycology & Parasitology
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC