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Benefit of Introgression Depends on Level of Genetic Trait Variation in Cereal Breeding Programmes

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posted on 2022-10-26, 02:47 authored by Y Li, F Shi, Z Lin, H Robinson, D Moody, A Rattey, J Godoy, D Mullan, G Keeble-Gagnere, Matthew HaydenMatthew Hayden, Josquin TibbitsJosquin Tibbits, Hans DaetwylerHans Daetwyler
We investigated the benefit from introgression of external lines into a cereal breeding programme and strategies that accelerated introgression of the favourable alleles while minimising linkage drag using stochastic computer simulation. We simulated genomic selection for disease resistance and grain yield in two environments with a high level of genotype-by-environment interaction (G × E) for the latter trait, using genomic data of a historical barley breeding programme as the base generation. Two populations (existing and external) were created from this base population with different allele frequencies for few (N = 10) major and many (N ~ 990) minor simulated disease quantitative trait loci (QTL). The major disease QTL only existed in the external population and lines from the external population were introgressed into the existing population which had minor disease QTL with low, medium and high allele frequencies. The study revealed that the benefit of introgression depended on the level of genetic variation for the target trait in the existing cereal breeding programme. Introgression of external resources into the existing population was beneficial only when the existing population lacked variation in disease resistance or when minor disease QTL were already at medium or high frequency. When minor disease QTL were at low frequencies, no extra genetic gain was achieved from introgression. More benefit in the disease trait was obtained from the introgression if the major disease QTL had larger effect sizes, more selection emphasis was applied on disease resistance, or more external lines were introgressed. While our strategies to increase introgression of major disease QTL were generally successful, most were not able to completely avoid negative impacts on selection for grain yield with the only exception being when major introgression QTL effects were very large. Breeding programmes are advised to carefully consider the level of genetic variation in a trait available in their breeding programme before deciding to introgress germplasms.

History

Publication Date

2022-06-15

Journal

Frontiers in Plant Science

Volume

13

Article Number

786452

Pagination

13p.

Publisher

Frontiers Media S.A.

ISSN

1664-462X

Rights Statement

© 2022 Li, Shi, Lin, Robinson, Moody, Rattey, Godoy, Mullan, Keeble-Gagnere, Hayden, Tibbits and Daetwyler. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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