1170366_Tran,S_2021.pdf (1.54 MB)
BECLIN1: Protein Structure, Function and Regulation
journal contributionposted on 2021-07-22, 05:03 authored by Sharon TranSharon Tran, Walter FairlieWalter Fairlie, Erinna LeeErinna Lee
BECLIN1 is a well-established regulator of autophagy, a process essential for mammalian survival. It functions in conjunction with other proteins to form Class III Phosphoinositide 3-Kinase (PI3K) complexes to generate phosphorylated phosphatidylinositol (PtdIns), lipids essential for not only autophagy but other membrane trafficking processes. Over the years, studies have elucidated the structural, biophysical, and biochemical properties of BECLIN1, which have shed light on how this protein functions to allosterically regulate these critical processes of autophagy and membrane trafficking. Here, we review these findings and how BECLIN1’s diverse protein interactome regulates it, as well as its impact on organismal physiology.
E.F.L. is a recipient of fellowships from the Australian Research Council (Future Fellowship FT150100212) and the Victorian Cancer Agency (Mid-Career Fellowship MCRF19045). S.T. is a recipient of a La Trobe University Graduate Research Scholarship/Research Training Program Scholarship.
Article NumberARTN 1522
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