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Autism-associated synaptic mutations impact the gut-brain axis in mice

journal contribution
posted on 01.12.2020, 22:46 by Chalystha Yie Qin Lee, Ashley FranksAshley Franks, EL Hill-Yardin
© 2020 The Authors Interactions between the gut microbiome and the brain affect mood and behaviour in health and disease. Using preclinical animal models, recent discoveries begin to explain how bacteria in the gut influence our mood as well as highlighting new findings relevant to autism. Autism-associated gene mutations known to alter synapse function in the CNS also affect inflammatory response and modify the enteric nervous system resulting in abnormal gastrointestinal motility and structure. Strikingly, these mutations additionally affect the gut microbiome in mice. This review describes the changes in gut physiology and microbiota in mouse models of autism with modified synapse function. The rationale for different regions of the gastrointestinal tract having variable susceptibility to dysfunction is also discussed. To dissect underlying biological mechanisms involving gut-brain axis dysfunction in preclinical models, a range of multidisciplinary approaches are required. This research will provide insights into the role of the gut-brain axis in health and neurodevelopmental disorders including autism.

Funding

CYQL, AEF and ELH-Y wrote the manuscript. All authors approved the manuscript for submission. ELH-Y was supported by an ARC Future Fellowship (FT160100126) and an RMIT Vice Chancellor's Senior Research Fellowship. CYQL received the RMIT Research Stipend Scholarship (RRSS).

History

Publication Date

01/08/2020

Journal

Brain, Behavior, and Immunity

Volume

88

Pagination

8p. (p. 275-282)

Publisher

Elsevier

ISSN

0889-1591

Rights Statement

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