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Autism-associated synaptic mutations impact the gut-brain axis in mice
journal contributionposted on 2020-12-01, 22:46 authored by Chalystha Yie Qin Lee, Ashley FranksAshley Franks, EL Hill-Yardin
© 2020 The Authors Interactions between the gut microbiome and the brain affect mood and behaviour in health and disease. Using preclinical animal models, recent discoveries begin to explain how bacteria in the gut influence our mood as well as highlighting new findings relevant to autism. Autism-associated gene mutations known to alter synapse function in the CNS also affect inflammatory response and modify the enteric nervous system resulting in abnormal gastrointestinal motility and structure. Strikingly, these mutations additionally affect the gut microbiome in mice. This review describes the changes in gut physiology and microbiota in mouse models of autism with modified synapse function. The rationale for different regions of the gastrointestinal tract having variable susceptibility to dysfunction is also discussed. To dissect underlying biological mechanisms involving gut-brain axis dysfunction in preclinical models, a range of multidisciplinary approaches are required. This research will provide insights into the role of the gut-brain axis in health and neurodevelopmental disorders including autism.
CYQL, AEF and ELH-Y wrote the manuscript. All authors approved the manuscript for submission. ELH-Y was supported by an ARC Future Fellowship (FT160100126) and an RMIT Vice Chancellor's Senior Research Fellowship. CYQL received the RMIT Research Stipend Scholarship (RRSS).
JournalBrain, Behavior, and Immunity
Pagination8p. (p. 275-282)
Rights StatementThe Author reserves all moral rights over the deposited text and must be credited if any re-use occurs. Documents deposited in OPAL are the Open Access versions of outputs published elsewhere. Changes resulting from the publishing process may therefore not be reflected in this document. The final published version may be obtained via the publisher’s DOI. Please note that additional copyright and access restrictions may apply to the published version.
Science & TechnologyLife Sciences & BiomedicineImmunologyNeurosciencesPsychiatryNeurosciences & NeurologyAutismSynaptic mutationEnteric nervous systemEpithelial barrier functionNeuroimmuneBrainSPECTRUM DISORDERMOUSE MODELMICROBIOTASYMPTOMSHEALTHIMMUNEABNORMALITIESCHILDRENBEHAVIORNETWORKNeurology & Neurosurgery