Association of visceral adiposity index with incident nephropathy and retinopathy: a cohort study in the diabetic population

Wu, Z; Yu, S; Kang, X; Liu, Y; Xu, Z; Li, Z; Wang, J; Miao, X; Liu, X; Li, Xia; Zhang, J; Wang, W; Tao, L; Guo, X

doi:10.26181/20128583.v1

Association of visceral adiposity index with incident nephropathy and retinopathy: a cohort study in the diabetic population

journal contribution

posted on 2022-06-23, 03:35 authored by Z Wu, S Yu, X Kang, Y Liu, Z Xu, Z Li, J Wang, X Miao, X Liu, Xia LiXia Li, J Zhang, W Wang, L Tao, X Guo

Background: The association between visceral adiposity index (VAI) and diabetic complications has been reported in cross-sectional studies, while the effect of VAI on complication development remains unclear. This study aims to evaluate the longitudinal association of VAI and Chinese VAI (CVAI) with the incidence of diabetic nephropathy and retinopathy using a Chinese cohort. Methods: A total of 8 948 participants with type 2 diabetes from Beijing Health Management Cohort were enrolled during 2013–2014, and followed until December 31, 2019. Nephropathy was confirmed by urine albumin/creatinine ratio and estimated glomerular filtration rate; retinopathy was diagnosed using fundus photograph. Results: The mean (SD) age was 53.35 (14.66) years, and 6 154 (68.8%) were men. During a median follow-up of 4.82 years, 467 participants developed nephropathy and 90 participants developed retinopathy. One-SD increase in VAI and CVAI levels were significantly associated with an increased risk of nephropathy, and the adjusted hazard ratios (HR) were 1.127 (95% CI 1.050–1.210) and 1.165 (95% CI 1.003–1.353), respectively. On contrary, VAI and CVAI level were not associated with retinopathy after adjusting confounding factors. Conclusion: VAI and CVAI are independently associated with the development of nephropathy, but not retinopathy in Chinese adults with diabetes.

Funding

Our work was funded by the National Natural Science Foundation of China (Numbers: 81872708 and 82073668).

History

Publication Date

2022-12-01

Journal

Cardiovascular Diabetology

Volume

21

Issue

1

Article Number

ARTN 32

Pagination

9p.

Publisher

BMC

ISSN

1475-2840

Rights Statement

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