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Association of Toll-like receptors 4 (TLR-4) gene expression and polymorphisms in patients with severe asthma

journal contribution
posted on 17.01.2022, 00:13 authored by W Shukur, K Alyaqubi, R Dosh, A Al-Ameri, Hayder Al-AubaidyHayder Al-Aubaidy, R Al-Maliki, A Aridhee, R Al-Fatlawi, N Hadi
Innate immunity plays a central role in the pathogenesis of severe asthma, and it is closely linked to elevated IgE and Toll-like receptor 4 (TLR-4) levels. However, there is a scarcity of information about the association of the TLR-4 receptor polymorphism in the pathogenesis of severe asthma. This study highlights the level of gene expression of different alleles in asthmatic patients compared to healthy control individuals. This was a randomized control trial, which included 150 patients with asthma (with high serum levels of IgE) with a matching 150 healthy control individuals. Participants had a series of blood tests to measure various immune parameters: interleukin-1 (IL-1), interleukin-6 (IL-6), tumor necrosis factor (TNF), intercellular adhesion molecule-1 (ICAM1) and detect allele type and gene expression of the TLR-4 gene. Patients with asthma had significantly higher levels of IL-8 when compared to the healthy control participants. In addition, in the rs91 genotyping, there were significant differences in the levels of IL-8 and TNF between CC and TT genotyping. While in rs90 TLR-4, TNF levels were significantly higher in AA vs. AG and GG genotypes among the asthmatic patients when compared to the control group. The results showed that in TLR-4, rs4986791 were significantly associated with asthma risk. Polymorphisms in TLRs play essential roles in asthma.

History

Publication Date

01/07/2021

Journal

Journal of Medicine and Life

Volume

14

Issue

4

Pagination

5p. (p. 544-548)

Publisher

Carol Davila University Press, Romania

ISSN

1844-122X

Rights Statement

© Journal of Medicine and Life. Limited to non-commercial access and personal use by others - the copyright for this article is held by the Journal of Medicine and Life; for all other uses, the Authors must request permission from Journal of Medicine and Life at office@medandlife.org to reproduce or authorize the reproduction of the Work or material extracted verbatim from the Work, including figures and tables.

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