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Assessing the Efficacy of Cell Transplantation for Parkinson’s Disease: A Patient-Centered Approach

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posted on 17.03.2022, 22:25 authored by Stephen PolgarStephen Polgar, Leila KarimiLeila Karimi, Melissa BuultjensMelissa Buultjens, Meg MorrisMeg Morris, Monica Busse
Background: Evidence from a growing number of preclinical studies indicate that recently discovered stem cell lines may be translated into viable cellular therapies for people with Parkinson's disease. Objectives: In a brief but critical review, we examine the use of primary and secondary outcome measures currently used to evaluate the efficacy of cellular therapies. Methods: The current practice of relying on a single primary outcome measure does not appear to provide the evidence required for demonstrating the robust, life-changing recovery anticipated with the successful implementation of cellular therapies. Results: We propose a 360-degree assessment protocol, which includes co-primary and composite outcome measures to provide accurate and comprehensive evidence of treatment efficacy, from the perspectives of both the researchers and the patients.

History

Publication Date

14/08/2018

Journal

Journal of Parkinson's Disease

Volume

8

Issue

3

Pagination

9p. (p. 375-383)

Publisher

IOS Press

ISSN

1877-7171

Rights Statement

© 2018 – IOS Press and the authors. All rights reserved. This article is published online with Open Access and distributed under the terms of the Creative Commons Attribution Non-Commercial License (CC BY-NC 4.0).

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