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Antimicrobial host defence peptides: functions and clinical potential
journal contributionposted on 2021-02-15, 05:31 authored by Neeloffer Mookherjee, Marilyn AndersonMarilyn Anderson, Henk P Haagsman, Donald J Davidson
© 2020, Springer Nature Limited. Cationic host defence peptides (CHDP), also known as antimicrobial peptides, are naturally occurring peptides that can combat infections through their direct microbicidal properties and/or by influencing the host’s immune responses. The unique ability of CHDP to control infections as well as resolve harmful inflammation has generated interest in harnessing the properties of these peptides to develop new therapies for infectious diseases, chronic inflammatory disorders and wound healing. Various strategies have been used to design synthetic optimized peptides, with negligible toxicity. Here, we focus on the progress made in understanding the scope of functions of CHDP and the emerging potential clinical applications of CHDP-based therapies.
N.M. is supported by the Canadian Institutes of Health Research and the Natural Sciences and Engineering Research Council Canada for peptide research. M.A.A. is supported by the Australian Research Council. H.P.H. is supported by NWO-ZonMW and NWO-TTW Perspectief grants. D.J.D. is supported by the British Skin Foundation (026/s/17), Action Medical Research (GN2703) and the Chief Scientist Office (TCS/18/02). The authors also gratefully acknowledge Y. Gasper and M. Bleackley, La Trobe University, for their assistance with tables and figures.
JournalNature Reviews Drug Discovery
Pagination22p. (p. 311-332)
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Science & TechnologyLife Sciences & BiomedicineBiotechnology & Applied MicrobiologyPharmacology & PharmacyHERPES-SIMPLEX-VIRUSHUMAN CATHELICIDIN LL-37PLASMACYTOID DENDRITIC CELLSHUMAN ALPHA-DEFENSININFLUENZA-A VIRUSDIRECT ANTIVIRAL ACTIVITYLUNG MUCOSAL IMMUNITYTHETA-DEFENSINSIN-VITROREGULATOR PEPTIDEAnimalsHumansCommunicable DiseasesInflammationAntimicrobial Cationic PeptidesAnti-Bacterial Agents