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Antibody-drug conjugates: beyond current approvals and potential future strategies

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journal contribution
posted on 20.05.2022, 03:37 authored by Siddharth MenonSiddharth Menon, Sagun ParakhSagun Parakh, Andrew ScottAndrew Scott, Hui GanHui Gan
The recent approvals for antibody-drug conjugates (ADCs) in multiple malignancies in recent years have fuelled the ongoing development of this class of drugs. These novel agents combine the benefits of high specific targeting of oncogenic cell surface antigens with the additional cell kill from high potency cytotoxic payloads, thus achieving wider therapeutic windows. This review will summarise the clinical activity of ADCs in tumour types not covered elsewhere in this issue, such as gastrointestinal (GI) and genitourinary (GU) cancers and glioblastoma (GBM). In addition to the ongoing clinical testing of existing ADCs, there is substantial preclinical and early phase testing of newer ADCs or ADC incorporating strategies. This review will provide selected insights into such future development, focusing on the development of novel ADCs against new antigen targets in the tumour microenvironment (TME) and combination of ADCs with immuno-oncology (IO) agents.

History

Publication Date

01/01/2022

Journal

Exploration of Targeted Anti-tumor Therapy

Volume

3

Issue

2

Pagination

(p. 252-277)

Publisher

Open Exploration Publishing

ISSN

2692-3114

Rights Statement

© The Author(s) 2022. This is an Open Access article licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, sharing, adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.