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Adaptive Behaviour and Cognitive Skills: Stability and Change from 7 Months to 7 Years in Siblings at High Familial Risk of Autism Spectrum Disorder

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posted on 28.03.2022, 04:23 by E Salomone, E Shephard, B Milosavljevic, MH Johnson, T Charman, S Baron-Cohen, R Bedford, P Bolton, S Chandler, M Elsabbagh, J Fernandes, H Garwood, T Gliga, Kristelle HudryKristelle Hudry, EJH Jones, G Pasco, A Pickles, L Tucker, A Volein
Cognitive and adaptive behaviour abilities early in life provide important clinical prognostic information. We examined stability of such skills in children at high familial risk for ASD who either met diagnostic criteria for ASD at age 7 years (HR-ASD, n = 15) or did not (HR-non-ASD, n = 24) and low-risk control children (LR, n = 37), prospectively studied from infancy. For both HR groups, cognitive skills were consistently lower across time than those of LR children. HR-ASD children showed increasing difficulties in adaptive behaviour over time compared to LR children, while the HR-non-ASD children showed no such difficulties. This pattern of change may inform our understanding of developmental profiles of HR siblings beyond core ASD symptoms.


The Research was supported by the BASIS funding consortium led by Autistica (, Autism Speaks, UK Medical Research Council Programme Grants (G0701484 and MR/K021389/1), as well as support from the Innovative Medicines Initiative Joint Undertaking under Grant Agreement No. 115300, resources of which are composed of financial contribution from the European Union's Seventh Framework Programme (FP7/2007-2013) and EFPIA companies' in kind contribution.


Publication Date



Journal of Autism and Developmental Disorders






11p. (p. 2901-2911)





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© The Author(s) 2018. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.