A phase 1b open-label study of sodium selenate as a disease-modifying treatment for possible behavioral variant frontotemporal dementia
journal contributionposted on 26.05.2022, 05:49 authored by Lucy Vivash, Charles B Malpas, Christian Meletis, Meghan Gollant, Dhamidhu Eratne, Qiao-Xin Li, Stuart McDonaldStuart McDonald, William T O'Brien, Amy Brodtmann, David Darby, Christopher Kyndt, Mark Walterfang, Christopher M Hovens, Dennis Velakoulis, Terence J O'Brien
Introduction: Sodium selenate increases tau dephosphorylation through protein phosphatase 2 activation. Here we report an open-label Phase 1b study of sodium selenate as a disease-modifying treatment for behavioral variant frontotemporal dementia (bvFTD). Methods: Twelve participants with bvFTD received sodium selenate (15 mg, three times a day) for 52 weeks. Safety assessments were carried out throughout the trial. Primary outcomes were frequency of adverse events (AEs), serious adverse events (SAEs), and discontinuations. Secondary outcomes of potential efficacy included cognitive and behavioral assessments, magnetic resonance imaging (MRI) whole brain volume, and cerebrospinal fluid (CSF) and blood total tau (t-tau), phosphorylated tau (p-tau), and neurofilament light (NfL) levels, which were measured at baseline and at week 52. Results: Sodium selenate was safe and well tolerated. All participants completed the study, and the majority (64.7%) of reported AEs were mild. One SAE occurred, which was not treatment related. Small declines in MRI and cognitive and behavioral measures were observed over the treatment period. There was no evidence for change in CSF protein levels (t-tau, p-tau, or NfL). Further analysis showed two distinct groups when measuring disease progression markers over the course of the study-one (n = 4) with substantial brain atrophy (2.5% to 6.5% reduction) and cognitive and behavioral decline over the 12-month treatment period, and the second group (n = 7) with no detectable change in cognitive and behavioral measures and less brain atrophy (0.3% to 1.7% reduction). Conclusion: Sodium selenate is safe and well tolerated in patients with bvFTD. Randomized-controlled trials are warranted to investigate potential efficacy.
The study authors thank the participants and their study partners and the study research nurses Chantelle Dowling and Lauren Hall. The study was funded by a philanthropic donation to the Royal Melbourne Hospital Neuroscience Foundation, and Medical Research Future Fund grants from the Australian Government (#MRF1170276, #MRF9100004) and a National Health and Medical Research Council Investigator Grant to TJO (#APP1176426).
JournalAlzheimer’s & Dementia: Translational Research & Clinical Interventions (TRCI)
Rights Statement© 2022 The Authors. Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, LLC on behalf of Alzheimer’s Association. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in anymedium, provided the original work is properly cited and is not used for commercial purposes.
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anti-tau treatmentbehavioral variant frontotemporal dementia (bvFTD)BRAINClinical Neurologyclinical trialfluid biomarkersfrontotemporal lobar degeneration (FTLD)Life Sciences & Biomedicinemagnetic resonance imaging (MRI)NEUROFILAMENT LIGHTNeurosciencesNeurosciences & Neurologyphosphorylated tauPROTEIN PHOSPHATASE 2Asafety and tolerabilityScience & TechnologytauTAUtherapeutic trialanti‐tau treatment