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A model of population dynamics with complex household structure and mobility: Implications for transmission and control of communicable diseases

journal contribution
posted on 11.12.2020, 03:55 by Rebecca Chisholm, B Crammond, Y Wu, AC Bowen, PT Campbell, SYC Tong, J McVernon, N Geard
Copyright 2020 Chisholm et al. Households are known to be high-risk locations for the transmission of communicable diseases. Numerous modelling studies have demonstrated the important role of households in sustaining both communicable diseases outbreaks and endemic transmission, and as the focus for control efforts. However, these studies typically assume that households are associated with a single dwelling and have static membership. This assumption does not appropriately reflect households in some populations, such as those in remote Australian Aboriginal and Torres Strait Islander communities, which can be distributed across more than one physical dwelling, leading to the occupancy of individual dwellings changing rapidly over time. In this study, we developed an individual-based model of an infectious disease outbreak in communities with demographic and household structure reflective of a remote Australian Aboriginal community. We used the model to compare the dynamics of unmitigated outbreaks, and outbreaks constrained by a householdfocused prophylaxis intervention, in communities exhibiting fluid vs. stable dwelling occupancy. We found that fluid dwelling occupancy can lead to larger and faster outbreaks in modelled scenarios, and may interfere with the effectiveness of household-focused interventions. Our findings suggest that while short-term restrictions on movement between dwellings may be beneficial during outbreaks, in the longer-term, strategies focused on reducing household crowding may be a more effective way to reduce the risk of severe outbreaks occurring in populations with fluid dwelling occupancy.

Funding

This work was supported by seed-funding from a NHMRC programme grant (1131932) and a NHMRC Centre of Research Excellence (APP1058804). There was no additional external funding received for this study The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

History

Publication Date

03/11/2020

Journal

PeerJ

Volume

8

Article Number

e10203

Pagination

17p.

Publisher

PeerJ

ISSN

2167-8359

Rights Statement

The Author reserves all moral rights over the deposited text and must be credited if any re-use occurs. Documents deposited in OPAL are the Open Access versions of outputs published elsewhere. Changes resulting from the publishing process may therefore not be reflected in this document. The final published version may be obtained via the publisher’s DOI. Please note that additional copyright and access restrictions may apply to the published version.

Licence

Exports