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7-O-Galloyltricetifavan: a promising natural radical scavenger

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posted on 2022-10-19, 22:16 authored by Le Trung Hieu, Tran ThiVan Thi, Nguyen Thi Hoa, Adam MechlerAdam Mechler, Quan Van VoQuan Van Vo
7-O-Galloyltricetifavan (7OGT), a natural flavonoid, is isolated from the leaves of Pithecellobium clypearia. The compound exhibits a variety of biological activities. This study details the evaluation of the HOO• antiradical activity of 7OGT by quantum chemistry calculations. The HOO• trapping activity of 7OGT in the gas phase (reference state) was discovered to follow the formal hydrogen transfer mechanism with a rate constant of k = 4.58 × 108 M-1 s-1. In physiological environments, 7OGT is predicted to be an excellent HOO• radical scavenger with k overall = 2.65 × 108 and 1.40 × 104 M-1 s-1 in water and pentyl ethanoate solvents, respectively. The HOO• antiradical activity of 7OGT in water at physiological pH is approximately 2000 times that of Trolox and substantially higher than that of other well-known natural antioxidants such as trans-resveratrol or ascorbic acid. Thus, 7OGT is an excellent natural antioxidant in polar environments.

Funding

The authors acknowledge the support of Hue University under the Core Research Group Program, grant no.NCM.DHH.2020.05. This research was funded by the Vietnamese Ministry of Education and Training under project number B2020-DHH-15 (T.T.V.T)

History

Publication Date

2022-06-22

Journal

Royal Society of Open Science

Volume

9

Issue

6

Article Number

211906

Pagination

8p.

Publisher

The Royal Society of Chemistry Publishing

ISSN

2054-5703

Rights Statement

© 2022 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.

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