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Effects of herbal mouthwashes on plaque and inflammation control for patients with gingivitis: a systematic review and meta-analysis of randomised controlled trials

journal contribution
posted on 28.10.2020, 23:28 by H Cai, J Chen, Nirmala Perera, X Liang
© 2020 He Cai et al. Objective. The aim of this study was to evaluate the overall effects of herbal mouthwashes as supplements to daily oral hygiene on plaque and inflammation control compared with placebos and chlorhexidine mouthwashes in the treatment of gingivitis. Methods. PubMed, EMBASE, Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, and grey literature databases were searched. Only randomised controlled trials comparing herbal mouthwashes with placebos or chlorhexidine in the daily oral hygiene of patient with gingivitis were included to compare the effect of different mouthwashes on plaque and inflammation control. Results. A total of 13 studies satisfied the eligibility criteria, and 11 studies were included in meta-analyses. Significant differences were observed in favour of herbal mouthwashes compared with placebos in both plaque- and inflammation-related indices (Quigley-Hein Plaque Index, QHPI: WMD = -0.61, 95% CI (-0.80, -0.42), P<0.001; Gingival Index, GI: -0.28 (-0.51, -0.06), P=0.01; Modified Gingival Index, MGI: -0.59 (-1.08, -0.11), P=0.02; Gingival Bleeding Index, GBI: -0.06 (-0.09, -0.04), P<0.001). No significant difference was found between herbal and chlorhexidine mouthwashes. Conclusions. Herbal mouthwashes have potential benefits in plaque and inflammation control as supplements to the daily oral hygiene of patients with gingivitis. Although no difference was observed between herbal and CHX mouthwashes in the selected studies, further high-quality RCTs are needed for more firm support before advising patients with gingivitis about whether they can use herbal mouthwashes to substitute for CHX mouthwashes or not (PROSPERO registration number: CRD42019122841).

Funding

The authors would like to thank the China Scholarship Council for supporting He Cai and Junyu Chen and the Centre for Sport, Exercise and Osteoarthritis Research Versus Arthritis Postdoctoral Fellowship for supporting Nirmala K. Panagodage Perera. This work was supported by the Graduate Student's Research and Innovation Fund of Sichuan University (grant no. 2018YJSY108); the China Postdoctoral Science Foundation Funded Project (grant no. 2018M640931); the Science & Technology Key Research and Development Program of Sichuan Province (grant no. 2019YFS0142); and the Young Scientists Fund of the National Natural Science Foundation of China (grant no. 81901060).

China Scholarship Council

Centre for Sport, Exercise and Osteoarthritis Research Versus Arthritis Postdoctoral Fellowship

Graduate Student's Research and Innovation Fund of Sichuan University | 2018YJSY108

China Postdoctoral Science Foundation | 2018M640931

Science & Technology Key Research and Development Program of Sichuan Province | 2019YFS0142

Young Scientists Fund of the National Natural Science Foundation of China | 81901060

History

Publication Date

01/01/2020

Journal

Evidence-Based Complementary and Alternative Medicine

Volume

2020

Article Number

2829854

Pagination

16p. (p. 1-16)

Publisher

Hindawi

ISSN

1741-427X

Rights Statement

The Author reserves all moral rights over the deposited text and must be credited if any re-use occurs. Documents deposited in OPAL are the Open Access versions of outputs published elsewhere. Changes resulting from the publishing process may therefore not be reflected in this document. The final published version may be obtained via the publisher’s DOI. Please note that additional copyright and access restrictions may apply to the published version.

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