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Adherence to the 2018 World Cancer Research Fund/American Institute for Cancer Research Recommendations and Breast Cancer in the SUN Project

journal contribution
posted on 04.11.2020, 04:18 by R Barrios-Rodríguez, E Toledo, I Aguilera-Buenosvinos, A Romanos-Nanclares, JJ Jiménez-Moleón, Miguel Martinez-Gonzalez
© 2020 by the authors Licensee MDPI, Basel, Switzerland. A proportion of breast cancer cases are attributable to combined modifiable risk factors. The World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) has recently updated the recommendations for cancer prevention and a standard scoring system has been published. The aim of this study was to evaluate the association between compliance with the 2018 WCRF/AICR cancer prevention recommendations (Third Expert Report) and the risk of breast cancer in the SUN (“Seguimiento Universidad de Navarra”) prospective cohort. Spanish female university graduates, initially free of breast cancer, were included (n = 10,930). An 8-item score to measure compliance to the recommendations was built: body fat, physical activity, consumption of wholegrains/vegetables/fruit/beans, “fast foods”, red/processed meat consumption, sugar-sweetened drinks consumption, alcohol intake, and breastfeeding. A stratified analysis was conducted according to menopausal status. A non-significant inverse association was observed for overall breast cancer. The inverse association became statistically significant for post-menopausal breast cancer after multivariable adjustment (hazard ratio for >5 vs. ≤ 3 points = 0.27; 95% CI: 0.08-0.93). The results suggested that the possible inverse association with breast cancer was attributable to the combined effects of the different nutritional and lifestyle components.

Funding

The SUN Project was funded by the Spanish Government-Instituto de Salud Carlos III and the European Regional Development Fund (FEDER) (RD 06/0045, CIBER-OBN, Grants PI10/02658, PI10/02293, PI13/00615, PI14/01668, PI14/01798, PI14/01764, PI17/01795, and G03/140), the Navarra Regional Government (45/2011, 122/2014, 41/2016), and the University of Navarra.

Spanish Government-Instituto de Salud Carlos III | PI10/02658

Spanish Government-Instituto de Salud Carlos III | PI10/02293

Spanish Government-Instituto de Salud Carlos III | PI13/00615

Spanish Government-Instituto de Salud Carlos III | PI14/01668

Spanish Government-Instituto de Salud Carlos III | PI14/01798

Spanish Government-Instituto de Salud Carlos III | PI14/01764

Spanish Government-Instituto de Salud Carlos III | PI17/01795

Spanish Government-Instituto de Salud Carlos III | G03/140

European Regional Development Fund (FEDER) | RD 06/0045

European Regional Development Fund (FEDER) (CIBER-OBN) | PI10/02658

European Regional Development Fund (FEDER) (CIBER-OBN) | PI10/02293

European Regional Development Fund (FEDER) (CIBER-OBN) | PI13/00615

European Regional Development Fund (FEDER) (CIBER-OBN) | PI14/01668

European Regional Development Fund (FEDER) (CIBER-OBN) | PI14/01798

European Regional Development Fund (FEDER) (CIBER-OBN) | PI14/01764

European Regional Development Fund (FEDER) (CIBER-OBN) | PI17/01795

European Regional Development Fund (FEDER) (CIBER-OBN) | G03/140

Navarra Regional Government | 45/2011

Navarra Regional Government | 122/2014

Navarra Regional Government | 41/2016

University of Navarra

History

Publication Date

01/01/2020

Journal

Nutrients

Volume

12

Issue

7

Article Number

2076

Pagination

12p. (p. 1-12)

Publisher

Multidisciplinary Digital Publishing Institute (MDPI)

ISSN

2072-6643

Rights Statement

The Author reserves all moral rights over the deposited text and must be credited if any re-use occurs. Documents deposited in OPAL are the Open Access versions of outputs published elsewhere. Changes resulting from the publishing process may therefore not be reflected in this document. The final published version may be obtained via the publisher’s DOI. Please note that additional copyright and access restrictions may apply to the published version.

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