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A coumarin derivative-Cu2+complex-based fluorescent chemosensor for detection of biothiols

journal contribution
posted on 20.11.2020, 05:10 by NK Hien, M Van Bay, PD Tran, NT Khanh, ND Luyen, Quan Van Vo, DU Van, PC Nam, DT Quang
© The Royal Society of Chemistry. Herein, a novel fluorescent sensor has been developed for the detection of biothiols based on theoretical calculations of the stability constant of the complex between a Cu2+ ion and (E)-3-((2-(benzo[d]thiazol-2-yl)hydrazono)methyl)-7-(diethylamino) coumarin (BDC) as a fluorescent ligand. In this study, on the basis of density functional theory method, the Gibbs free energy of ligand-exchange reaction and the solvation model were carried out using thermodynamic cycles. The obtained results are in good agreement with the experimental data. The BDC-Cu2+ complex can be used as a fluorescent sensor for the detection of biothiols in the presence of non-thiol containing amino acids, with a detection limit for cysteine at 0.3 μM. Moreover, theoretical calculations of excited states were used to elucidate variations in the fluorescence properties. The computed results show that the excited doublet states D2 and D1 are dark doublet states, which quench the fluorescence of the complex.

Funding

This research was funded by the Vietnam National Foundation for Science and Technology Development (NAFOSTED) under grant number 104.06-2016.32 (Nguyen Khoa Hien).

History

Publication Date

01/10/2020

Journal

RSC Advances: an international journal to further the chemical sciences

Volume

10

Issue

60

Pagination

10p. (p. 36265-36274)

Publisher

Royal Society of Chemistry

ISSN

2046-2069

Rights Statement

The Author reserves all moral rights over the deposited text and must be credited if any re-use occurs. Documents deposited in OPAL are the Open Access versions of outputs published elsewhere. Changes resulting from the publishing process may therefore not be reflected in this document. The final published version may be obtained via the publisher’s DOI. Please note that additional copyright and access restrictions may apply to the published version.

Licence

Exports