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Poly(N-isopropylacrylamide) microgel synthesised by emulsion polymerization

conference contribution
posted on 31.03.2021, 05:45 by YHN Ernest, TK Yeow, LS Shee, Ing KongIng Kong
© 2020 Trans Tech Publications Ltd, Switzerland. Smart polymers have been one of the most popularly studied materials owing to their capability to alter physio-chemical behaviour upon exposure to specific external stimuli. The biocompatible thermally responsive poly(N-isopropylacrylamide), PNIPAm shows reversible transition between hydrophilic-hydrophobic characteristics at the vicinity of human physiological temperature has great potential to propel the development of smart tissue engineering scaffold and drug delivery. However, the limited availability and its high cost have dampened the extent of research on this polymer. To address these challenges, the current work demonstrates an economical lab-scale polymerization of crosslinked PNIPAm and the optimised parameters to produce mono-dispersed polymer hydrogel particles were investigated. Characterisation of the synthesized PNIPAm polymer revealed particle size polydispersity index of 0.215, indicative of distribution within the mono-dispersed range, with average hydrodynamic diameter of 346.3 nm. Zeta-potential of the synthesized PNIPAm was found to be-20.6 mV, suggesting an incipient instability in terms of colloidal coagulation. Viscosity of the synthesized PNIPAm (4 wt% concentration in methanol) was 28.6 cP. Thermal gravimetric analysis (TGA) indicated the thermal degradation of main chain PNIPAm fell in the range of 340 to 480°C.

History

Publication Date

01/01/2020

Proceedings

Solid State Phenomena

Editors

Suhaimi S Ozair LN Khalil A

Publisher

Trans Tech Publications

Place of publication

Switzerland

Volume

307

Pagination

6p. (p. 345-350)

ISBN-13

9783035714524

ISSN

1012-0394

Name of conference

Regional Conference of Solid State Science and Technology (RCSSST)

Location

Melaka, Malaysia

Starting Date

06/11/2018

Finshing Date

08/11/2018

Rights Statement

The Author reserves all moral rights over the deposited text and must be credited if any re-use occurs. Documents deposited in OPAL are the Open Access versions of outputs published elsewhere. Changes resulting from the publishing process may therefore not be reflected in this document. The final published version may be obtained via the publisher’s DOI. Please note that additional copyright and access restrictions may apply to the published version.

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